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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 162

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
CDON cis Discovery rs3740909 11:125,889,526 C/T 0.07 993 -0.829 0.078 4.4×10-25 -1.170 7.7×10-26 6.6×10-21
CDON cis Replication rs3740909 11:125,889,526 G/A 0.11 337 -0.542 0.100 1.1×10-7 -1.160 1.4×10-8 5.9×10-7

 

Regional association plots

Cell adhesion molecule-related/down-regulated by oncogenes (CDON)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Cell adhesion molecule-related/down-regulated by oncogenes (CDON)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Cell adhesion molecule-related/down-regulated by oncogenes (CDON)

Target (abbrv.) CDON
Target (full name) Cell adhesion molecule-related/down-regulated by oncogenes
Somalogic ID (Sequence ID) SL014092 (4541-49_2)
Entrez Gene Symbol CDON
UniProt ID Q4KMG0
UniProt Comment
  • Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).
Pathway Interaction Database
  • Signaling events mediated by the Hedgehog family
Reactome
  • CDO in myogenesis
  • Ligand-receptor interactions

All locus annotations are based on the sentinel SNP (rs3740909) and 42 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
  • CDON cell adhesion associated, oncogene regulated

 

Results from other genome-wide association studies

Trait P Study Source
Chronic lymphocytic leukemia/small lymphocytic lymphoma 2.2×10-5 20639881 (PMID) GRASP2 nonQTL
cg07498426 (chr11:125952718) 2.9×10-5 10.1101/033084 (DOI) BIOS QTL cis-meQTLs