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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 187

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
IP-10 cis Discovery rs11548618 4:76,943,947 G/A 0.01 997 1.841 0.191 4.9×10-21 2.790 7.2×10-36 1.4×10-4

 

Regional association plots

 

Boxplots and histograms for top associations

C-X-C motif chemokine 10 (IP-10)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

C-X-C motif chemokine 10 (IP-10)

Target (abbrv.) IP-10
Target (full name) C-X-C motif chemokine 10
Somalogic ID (Sequence ID) SL003183 (4141-79_1)
Entrez Gene Symbol CXCL10
UniProt ID P02778
UniProt Comment
  • Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
Targeted by drugs (based on IPA annotation)
  • MDX-1100
Biomarker applications (based on IPA annotation)
  • diagnosis
  • efficacy
  • unspecified application
Wiki Pathways
  • Regulation of toll-like receptor signaling pathway
  • Toll-like receptor signaling pathway
  • Type II interferon signaling (IFNG)
Pathway Interaction Database
  • CXCR3-mediated signaling events
Reactome
  • Chemokine receptors bind chemokines
  • G alpha (i) signalling events
Pathway Studio
  • Nociception-related CCR1 expression targets
  • Summarized nociception-related expression targets

All locus annotations are based on the sentinel SNP (rs11548618).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
  • ART3 ADP-ribosyltransferase 3
  • CXCL10 chemokine (C-X-C motif) ligand 10

 

Results from other genome-wide association studies


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No associations available.