HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 188

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
CLM6 trans Discovery rs10858881 12:89,891,474 T/G 0.22 996 -0.501 0.052 5.1×10-21 -1.110 4.4×10-19 3.1×10-12
CLM6 trans Replication rs10858897 12:89,922,032 C/A 0.30 337 -0.243 0.065 2.1×10-4 -1.070 0.001 0.013

 

Regional association plots

 

Boxplots and histograms for top associations

CMRF35-like molecule 6 (CLM6)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

CMRF35-like molecule 6 (CLM6)

Target (abbrv.) CLM6
Target (full name) CMRF35-like molecule 6
Somalogic ID (Sequence ID) SL014270 (5066-134_3)
Entrez Gene Symbol CD300C
UniProt ID Q08708
UniProt Comment
  • Cell membrane

All locus annotations are based on the sentinel SNP (rs10858881) and 75 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
eQTL genes

 

Results from other genome-wide association studies

Trait P Study Source
cg16606638 (chr12:89918245) 1.4×10-216 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg18474081 (chr12:89923517) 5.6×10-14 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of GALNT4 in peripheral blood monocytes 1.6×10-12 20502693 (PMID) GRASP2 eQTL
Gene expression of WDR51B in blood 2.2×10-7 21829388 (PMID) GRASP2 eQTL
Gene expression of ATP2B1 in blood 1.6×10-6 21829388 (PMID) GRASP2 eQTL
Differential exon level expression of WDR51B [probe 3464936] in brain cortex 4.6×10-6 19222302 (PMID) GRASP2 eQTL
Gene expression of GALNT4 in CD4+ lymphocytes 4.9×10-6 20833654 (PMID) GRASP2 eQTL
Differential exon level expression of WDR51B [probe 3464935] in brain cortex 9.7×10-6 19222302 (PMID) GRASP2 eQTL
Gene expression of GALNT4 in liver 1.9×10-5 18462017 (PMID) GRASP2 eQTL
Systolic blood pressure 3.9×10-4 21909115 (PMID) Supplemental file
Systolic blood pressure (SBP) 3.9×10-4 21909115 (PMID) GRASP2 nonQTL