HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 206

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
MICB cis Discovery rs1794282 6:32,666,526 C/T 0.08 990 -0.707 0.077 2.6×10-19 -1.230 1.8×10-7 0.251
MICB cis Replication rs9273327 6:32,623,223 A/C 0.10 337 0.017 0.112 0.878 -1.000 0.95 0.797

 

Regional association plots

MHC class I polypeptide-related sequence B (MICB)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

MHC class I polypeptide-related sequence B (MICB)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

MHC class I polypeptide-related sequence B (MICB)

Target (abbrv.) MICB
Target (full name) MHC class I polypeptide-related sequence B
Somalogic ID (Sequence ID) SL005200 (5102-55_3)
Entrez Gene Symbol MICB
UniProt ID Q29980
UniProt Comment
  • Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Biomarker applications (based on IPA annotation)
  • safety
Pathway Studio
  • Natural Killer Cell Activation
  • Natural Killer Cell Activation through C-type Lectin-like Receptors

All locus annotations are based on the sentinel SNP (rs1794282) and 52 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
Potentially regulated genes
eQTL genes
  • HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
  • HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
  • TNXB tenascin XB
  • C4A complement component 4A (Rodgers blood group)
  • HLA-C major histocompatibility complex, class I, C
  • HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene)
  • XXbac-BPG248L24.13
  • STK19B serine/threonine kinase 19B, pseudogene
  • CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
  • MICB MHC class I polypeptide-related sequence B
  • HLA-DMB major histocompatibility complex, class II, DM beta
  • STK19 serine/threonine kinase 19
  • HLA-DRB5 major histocompatibility complex, class II, DR beta 5
  • RNF5 ring finger protein 5, E3 ubiquitin protein ligase
  • NOTCH4 notch 4
  • HLA-DMA major histocompatibility complex, class II, DM alpha
  • C4B complement component 4B (Chido blood group)
  • LY6G6C lymphocyte antigen 6 complex, locus G6C
  • WASF5P WAS protein family, member 5, pseudogene
  • TNXA tenascin XA (pseudogene)
  • CYP21A1P cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene
  • VARS2 valyl-tRNA synthetase 2, mitochondrial
  • HCP5 HLA complex P5 (non-protein coding)
  • PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
  • HLA-DPB1 major histocompatibility complex, class II, DP beta 1
  • HLA-DQB1-AS1 HLA-DQB1 antisense RNA 1
  • HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
  • TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
  • XXbac-BPG246D15.9

 

Results from other genome-wide association studies

Trait P Study Source
cg24376689 (chr6:32016360) 2.2×10-129 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg19555708 (chr6:32159628) 4×10-129 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg11469594 (chr6:32783022) 7.1×10-121 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg26246658 (chr6:32936765) 8.3×10-117 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Diabetes mellitus, type 1 2.5×10-103 pha002862 (dbGaP) dbGaP via SNiPA
Type 1 diabetes, combined control dataset 7.6×10-98 17554300 (PMID) GRASP2 nonQTL
Gene expression of HLA-DRB5///HLA-DRB1 in blood 5.8×10-94 21829388 (PMID) GRASP2 eQTL
Myasthenia gravis 5.3×10-90 23055271 (PMID) GRASP2 nonQTL
cg21289669 (chr6:32064788) 1.1×10-71 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg03531211 (chr6:32920078) 9.3×10-70 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg11493661 (chr6:32016215) 1.2×10-69 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg08801479 (chr6:32165176) 5×10-63 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg11025918 (chr6:32165159) 5.8×10-62 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg19886087 (chr6:32335147) 2.6×10-61 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of HLA-DQA1///HLA-DQA2 in blood 2.9×10-52 21829388 (PMID) GRASP2 eQTL
cg03556669 (chr6:32064521) 1.3×10-50 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Systemic lupus erythematosus (SLE) (females) 2.6×10-46 18204446 (PMID) GRASP2 nonQTL
cg00874877 (chr6:32272074) 1.6×10-42 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg02989255 (chr6:32063798) 4.3×10-38 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg26988373 (chr6:32809474) 4×10-35 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg21535976 (chr6:31997050) 6.6×10-35 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg20414186 (chr6:32064515) 4.1×10-33 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg16662408 (chr6:32053661) 1.4×10-32 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg13563634 (chr6:32805708) 1.2×10-31 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg24421410 (chr6:32920196) 1.6×10-31 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg08516507 (chr6:32064230) 1.6×10-31 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg02806715 (chr6:32920543) 3.2×10-31 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg24129356 (chr6:32920759) 6.2×10-31 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg08735211 (chr6:32920633) 2×10-30 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg00933538 (chr6:32121495) 6.5×10-29 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg07151443 (chr6:32920938) 7.1×10-28 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Idiopathic membranous nephropathy 2.2×10-27 21323541 (PMID) GRASP2 nonQTL
cg09872737 (chr6:32076294) 5.8×10-27 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg17851795 (chr6:32158951) 2.2×10-26 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg25393613 (chr6:32055044) 6.6×10-26 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg12094903 (chr6:32808665) 1.3×10-25 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg05436760 (chr6:32149119) 2.7×10-25 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg03543593 (chr6:32076441) 5.6×10-25 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg06023661 (chr6:32164825) 8.2×10-25 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg03130418 (chr6:32063463) 4.6×10-24 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg19108771 (chr6:32076361) 6×10-23 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg21960265 (chr6:32015659) 1×10-22 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg23462632 (chr6:32038905) 1.9×10-22 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg08362880 (chr6:32053576) 4.5×10-22 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg06815976 (chr6:32164792) 5.5×10-22 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg08972588 (chr6:32014650) 1.9×10-21 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg04172115 (chr6:32053752) 1.6×10-20 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Schizophrenia 3.2×10-20 25056061 (PMID) Supplemental file
Rheumatoid arthritis 3.3×10-20 20453842 (PMID) GRASP2 nonQTL
cg20044211 (chr6:32186019) 1.1×10-19 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Type 1 diabetes 1.7×10-19 17632545 (PMID) GRASP2 nonQTL
cg12738718 (chr6:32121180) 1.1×10-18 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Lupus erythematosus, systemic 4×10-18 pha002848 (dbGaP) dbGaP via SNiPA
Gene expression of HLA-DRB1 [probe 221491_x_at] in lymphoblastoid cell lines 2.8×10-17 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB2 [probe 221491_x_at] in lymphoblastoid cell lines 2.8×10-17 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB3 [probe 221491_x_at] in lymphoblastoid cell lines 2.8×10-17 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB4 [probe 221491_x_at] in lymphoblastoid cell lines 2.8×10-17 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB5 [probe 221491_x_at] in lymphoblastoid cell lines 2.8×10-17 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133484 [probe 221491_x_at] in lymphoblastoid cell lines 2.8×10-17 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133661 [probe 221491_x_at] in lymphoblastoid cell lines 2.8×10-17 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133811 [probe 221491_x_at] in lymphoblastoid cell lines 2.8×10-17 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC730415 [probe 221491_x_at] in lymphoblastoid cell lines 2.8×10-17 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC731718 [probe 221491_x_at] in lymphoblastoid cell lines 2.8×10-17 17873877 (PMID) GRASP2 eQTL
Gene expression of RNASE2 [probe 221491_x_at] in lymphoblastoid cell lines 2.8×10-17 17873877 (PMID) GRASP2 eQTL
Gene expression of ZNF749 [probe 221491_x_at] in lymphoblastoid cell lines 2.8×10-17 17873877 (PMID) GRASP2 eQTL
cg02352370 (chr6:32054821) 8.6×10-17 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg04136321 (chr6:32093957) 1.1×10-16 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of HLA-DRB5 (probeID ILMN_1701686) in whole blood 1.4×10-16 22692066 (PMID) GRASP2 eQTL
Gene expression of [probe 1190754 centered at chr6:32731975] in blood 1.8×10-16 21829388 (PMID) GRASP2 eQTL
cg07088771 (chr6:32057870) 2.2×10-16 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of HLA-DQA1 [probe 203290_at] in lymphoblastoid cell lines 2.4×10-16 17873877 (PMID) GRASP2 eQTL
cg04628692 (chr6:32094891) 2.7×10-16 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of HLA-DRB1 probe[221491_x_at] in lymphoblastoid cell lines 3×10-16 17873877 (PMID) GRASP2 eQTL
cg15657588 (chr6:32075787) 3×10-16 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg09889836 (chr6:32035051) 3.8×10-16 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg03438552 (chr6:32805572) 1.7×10-15 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg09845996 (chr6:32094881) 1.9×10-15 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg09423875 (chr6:32014639) 2.2×10-15 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of HLA-DQA1 probe[203290_at] in lymphoblastoid cell lines 2.5×10-15 17873877 (PMID) GRASP2 eQTL
cg00617292 (chr6:32038982) 3.2×10-15 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Total cholesterol 4.4×10-15 24097068 (PMID) Supplemental file
cg13409674 (chr6:32014500) 4.5×10-15 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of HLA-DRB1 [probe 204670_x_at] in lymphoblastoid cell lines 4.7×10-15 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB2 [probe 204670_x_at] in lymphoblastoid cell lines 4.7×10-15 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB3 [probe 204670_x_at] in lymphoblastoid cell lines 4.7×10-15 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB4 [probe 204670_x_at] in lymphoblastoid cell lines 4.7×10-15 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB5 [probe 204670_x_at] in lymphoblastoid cell lines 4.7×10-15 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133484 [probe 204670_x_at] in lymphoblastoid cell lines 4.7×10-15 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133661 [probe 204670_x_at] in lymphoblastoid cell lines 4.7×10-15 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133811 [probe 204670_x_at] in lymphoblastoid cell lines 4.7×10-15 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC730415 [probe 204670_x_at] in lymphoblastoid cell lines 4.7×10-15 17873877 (PMID) GRASP2 eQTL
Gene expression of RNASE2 [probe 204670_x_at] in lymphoblastoid cell lines 4.7×10-15 17873877 (PMID) GRASP2 eQTL
Gene expression of ZNF749 [probe 204670_x_at] in lymphoblastoid cell lines 4.7×10-15 17873877 (PMID) GRASP2 eQTL
cg14737484 (chr6:32054585) 8.8×10-15 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg17272563 (chr6:32116572) 1.2×10-14 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg17940902 (chr6:32921209) 1.7×10-14 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg08998192 (chr6:32805594) 2.6×10-14 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of HLA-DRB1 probe[204670_x_at] in lymphoblastoid cell lines 4.7×10-14 17873877 (PMID) GRASP2 eQTL
cg11941520 (chr6:32121546) 6.2×10-14 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Triglycerides 9.5×10-14 24097068 (PMID) Supplemental file
cg21712377 (chr6:32829038) 9.8×10-14 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Rheumatoid arthritis (ACPA-positive) 3×10-13 21156761 (PMID) GRASP2 nonQTL
cg19154116 (chr6:32005762) 3×10-13 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg07481886 (chr6:32014486) 3.4×10-13 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Lung cancer 7.1×10-13 22899653 (PMID) GRASP2 nonQTL
cg10218546 (chr6:32729847) 8.7×10-13 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg27624229 (chr6:32049077) 1.4×10-12 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg21038932 (chr6:32730883) 1.8×10-12 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg12048225 (chr6:32808693) 2.1×10-12 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg26685246 (chr6:32805716) 2.6×10-12 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of HLA-DRB1 in lymphoblastoid cell lines 4.6×10-12 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DQB1 [probe 209480_at] in lymphoblastoid cell lines 4.9×10-12 17873877 (PMID) GRASP2 eQTL
cg12660777 (chr6:32154809) 9.6×10-12 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of HLA-DQB1 [probe 212999_x_at] in lymphoblastoid cell lines 1.1×10-11 17873877 (PMID) GRASP2 eQTL
cg22940798 (chr6:32805578) 1.9×10-11 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of HLA-DQA1 (probeID ILMN_1808405) in whole blood 4.2×10-11 22692066 (PMID) GRASP2 eQTL
Gene expression of HLA-DQB1 probe[209480_at] in lymphoblastoid cell lines 4.3×10-11 17873877 (PMID) GRASP2 eQTL
cg27428104 (chr6:32044472) 7.5×10-11 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of HLA-DQB1 probe[212999_x_at] in lymphoblastoid cell lines 9.6×10-11 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DQA1 [probe 213831_at] in lymphoblastoid cell lines 1.6×10-10 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DQB1 [probe 211654_x_at] in lymphoblastoid cell lines 1.9×10-10 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DQB1 in lymphoblastoid cell lines 2.5×10-10 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB4 in liver 3.6×10-10 22006096 (PMID) GRASP2 eQTL
cg19412007 (chr6:32825032) 3.7×10-10 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg27337194 (chr6:32036887) 4×10-10 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg14475758 (chr6:32920904) 6×10-10 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of HLA-DQA1 probe[213831_at] in lymphoblastoid cell lines 1.3×10-9 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB1 [probe 209312_x_at] in lymphoblastoid cell lines 1.5×10-9 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB2 [probe 209312_x_at] in lymphoblastoid cell lines 1.5×10-9 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB3 [probe 209312_x_at] in lymphoblastoid cell lines 1.5×10-9 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB4 [probe 209312_x_at] in lymphoblastoid cell lines 1.5×10-9 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB5 [probe 209312_x_at] in lymphoblastoid cell lines 1.5×10-9 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133484 [probe 209312_x_at] in lymphoblastoid cell lines 1.5×10-9 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133661 [probe 209312_x_at] in lymphoblastoid cell lines 1.5×10-9 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC100133811 [probe 209312_x_at] in lymphoblastoid cell lines 1.5×10-9 17873877 (PMID) GRASP2 eQTL
Gene expression of LOC730415 [probe 209312_x_at] in lymphoblastoid cell lines 1.5×10-9 17873877 (PMID) GRASP2 eQTL
Gene expression of RNASE2 [probe 209312_x_at] in lymphoblastoid cell lines 1.5×10-9 17873877 (PMID) GRASP2 eQTL
Gene expression of ZNF749 [probe 209312_x_at] in lymphoblastoid cell lines 1.5×10-9 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DQB1 probe[211654_x_at] in lymphoblastoid cell lines 1.6×10-9 17873877 (PMID) GRASP2 eQTL
cg05119374 (chr6:32399375) 2×10-9 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg24125828 (chr6:32117025) 2×10-9 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg14570531 (chr6:32168727) 2.2×10-9 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg21798061 (chr6:32329464) 2.4×10-9 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of HLA-DRA (probeID ILMN_2157441) in cerebellum in Alzheimer's disease cases and controls 3.8×10-9 22685416 (PMID) GRASP2 eQTL
Gene expression of HLA-DRA (probeID ILMN_2157441) in temporal cortex in Alzheimer's disease cases and controls 4.1×10-9 22685416 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB1 probe[209312_x_at] in lymphoblastoid cell lines 1.1×10-8 17873877 (PMID) GRASP2 eQTL
cg04344233 (chr6:32027403) 2.5×10-8 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg25375757 (chr6:32014715) 3.4×10-8 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg08117728 (chr6:32179543) 5.2×10-8 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of HLA-DQB1 [probe 212998_x_at] in lymphoblastoid cell lines 5.4×10-8 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB4 [probe 209728_at] in lymphoblastoid cell lines 5.4×10-8 17873877 (PMID) GRASP2 eQTL
Alopecia areata 6×10-8 20596022 (PMID) GRASP2 nonQTL
Height 6.2×10-8 25282103 (PMID) Supplemental file
cg05483184 (chr6:32055369) 7.6×10-8 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg00254681 (chr6:32118433) 1.1×10-7 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of HLA-DRB2 in blood cells in Celiac disease 1.2×10-7 19128478 (PMID) GRASP2 eQTL
Gene expression of probe[237865_x_at] in lymphoblastoid cell lines 3×10-7 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB4 probe[209728_at] in lymphoblastoid cell lines 3.8×10-7 17873877 (PMID) GRASP2 eQTL
Gene expression of HLA-DQB1 probe[212998_x_at] in lymphoblastoid cell lines 3.8×10-7 17873877 (PMID) GRASP2 eQTL
Gene expression of PSMB9 in blood 5.3×10-7 21829388 (PMID) GRASP2 eQTL
Waist-to-hip ratio, adjusted for BMI 8.5×10-7 25673412 (PMID) Supplemental file
cg15418419 (chr6:32916630) 9.4×10-7 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg18031239 (chr6:32918395) 1.6×10-6 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg22851080 (chr6:32044380) 1.7×10-6 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg00624949 (chr6:32134596) 1.7×10-6 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg08732684 (chr6:32095152) 3.1×10-6 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg18505752 (chr6:32808728) 5.2×10-6 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg20116128 (chr6:32160980) 7.8×10-6 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of MICA in normal prepouch ileum 1.2×10-5 23474282 (PMID) GRASP2 eQTL
Inflammatory bowel disease 2.1×10-5 Supplemental file
Cross-disorder, subset Schizophrenia 2.1×10-5 23453885 (PMID) Supplemental file
Bipolar disorder vs. Schizophrenia 2.1×10-5 24280982 (PMID) Supplemental file
cg04182226 (chr6:32014276) 2.8×10-5 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg21869704 (chr6:32134598) 3.3×10-5 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg21800193 (chr6:32186769) 3.3×10-5 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg23588029 (chr6:32137142) 3.4×10-5 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg05323467 (chr6:32121734) 4.7×10-5 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg15670990 (chr6:32016139) 5.2×10-5 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg23464264 (chr6:32145947) 5.5×10-5 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Advanced age-related macular degeneration (choroidal neovascularization) vs. no AMD 5.9×10-5 23455636 (PMID) GRASP2 nonQTL
Waist-to-hip ratio 6×10-5 25673412 (PMID) Supplemental file
cg03282991 (chr6:32294284) 6×10-5 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
LDL cholesterol 6.7×10-5 24097068 (PMID) Supplemental file
Advanced age-related macular degeneration 9.6×10-5 23455636 (PMID) GRASP2 nonQTL
cg05569328 (chr6:32044360) 1.1×10-4 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Waist circumfence, adjusted for BMI 1.3×10-4 25673412 (PMID) Supplemental file
Crohn's disease 1.8×10-4 Supplemental file
Waist hip ratio 2.3×10-4 20935629 (PMID) GRASP2 nonQTL
Gene expression of HLA-DQB1 [probeset 212999_x_at] in sputum 2.4×10-4 21949713 (PMID) GRASP2 eQTL