Connecting genetic risk to disease endpoints through the human blood plasma proteome
ONLINE SUPPLEMENTARY INFORMATION
Locus annotations
Locus 242
Top associations per target
| Target | cis/trans | Study | SNP | SNP location | Maj/min allele | MAF | N | βinv | seinv | Pinv | fclog | Plog | Praw |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RAP | trans | Discovery | rs9468569 | 6:29,623,315 | G/A | 0.01 | 997 | 1.631 | 0.193 | 9.6×10-17 | 2.450 | 1.3×10-49 | 1×10-52 |
Regional association plots
alpha-2-macroglobulin receptor-associated protein (RAP)
Boxplots and histograms for top associations
alpha-2-macroglobulin receptor-associated protein (RAP)
| inverse-normalized probe levels | log2 transformed probe levels | raw probe levels | |
|---|---|---|---|
| Discovery study |
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alpha-2-macroglobulin receptor-associated protein (RAP)
| Target (abbrv.) | RAP |
| Target (full name) | alpha-2-macroglobulin receptor-associated protein |
| Somalogic ID (Sequence ID) | SL005263 (3640-14_3) |
| Entrez Gene Symbol | LRPAP1 |
| UniProt ID | P30533 |
| UniProt Comment |
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| Pathway Interaction Database |
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All locus annotations are based on the sentinel SNP (rs9468569) and 26 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)
Linked genes
| Genes hit or close-by | |
| Potentially regulated genes |
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Results from other genome-wide association studies
| Trait | P | Study | Source |
|---|---|---|---|
| Height | 2.7×10-5 | 25282103 (PMID) | Supplemental file |