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Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 260

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
MICB cis Discovery rs2534674 6:31,465,103 C/T 0.35 995 0.358 0.044 6.9×10-16 1.100 1.1×10-5 0.401

 

Regional association plots

MHC class I polypeptide-related sequence B (MICB)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

MHC class I polypeptide-related sequence B (MICB)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

MHC class I polypeptide-related sequence B (MICB)

Target (abbrv.) MICB
Target (full name) MHC class I polypeptide-related sequence B
Somalogic ID (Sequence ID) SL005200 (5102-55_3)
Entrez Gene Symbol MICB
UniProt ID Q29980
UniProt Comment
  • Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Biomarker applications (based on IPA annotation)
  • safety
Pathway Studio
  • Natural Killer Cell Activation
  • Natural Killer Cell Activation through C-type Lectin-like Receptors

All locus annotations are based on the sentinel SNP (rs2534674) and 8 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
  • Y_RNA
  • MICB MHC class I polypeptide-related sequence B
eQTL genes
  • HCP5 HLA complex P5 (non-protein coding)
  • XXbac-BPG248L24.12
  • MUC22 mucin 22
  • MICB MHC class I polypeptide-related sequence B
  • HCG22 HLA complex group 22
  • HCG27 HLA complex group 27 (non-protein coding)
  • LST1 leukocyte specific transcript 1
  • HLA-DRB5 major histocompatibility complex, class II, DR beta 5
  • HLA-C major histocompatibility complex, class I, C
  • HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene)

 

Results from other genome-wide association studies

Trait P Study Source
Gene expression of HLA-DRB1 in peripheral blood monocytes 2.7×10-19 20502693 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB5 in peripheral blood monocytes 2×10-17 20502693 (PMID) GRASP2 eQTL
Gene expression of HLA-DRB6 in peripheral blood monocytes 6.1×10-17 20502693 (PMID) GRASP2 eQTL
Gene expression of LST1 in peripheral blood monocytes 8.9×10-13 20502693 (PMID) GRASP2 eQTL
Gene expression of HLA-C in peripheral blood monocytes 2.6×10-12 20502693 (PMID) GRASP2 eQTL
Height 1.9×10-9 25282103 (PMID) Supplemental file
Rheumatoid arthritis 2.5×10-9 20453842 (PMID) GRASP2 nonQTL
Gene expression of HSPA1L in peripheral blood monocytes 2.2×10-8 20502693 (PMID) GRASP2 eQTL
Gene expression of IER3 in peripheral blood monocytes 2.3×10-8 20502693 (PMID) GRASP2 eQTL
Gene expression of TNF in peripheral blood monocytes 3.1×10-8 20502693 (PMID) GRASP2 eQTL
Ulcerative collitis 4.8×10-8 Supplemental file
Inflammatory bowel disease 1.5×10-7 Supplemental file
Dengue shock syndrome in adolescents 8.5×10-7 22001756 (PMID) GRASP2 nonQTL
Gene expression of LTA in peripheral blood monocytes 1.3×10-6 20502693 (PMID) GRASP2 eQTL
Gene expression of HCG27 in peripheral blood monocytes 4.4×10-6 20502693 (PMID) GRASP2 eQTL
Gene expression of MED21 in peripheral blood monocytes 8×10-6 20502693 (PMID) GRASP2 eQTL
Type 2 diabetes 9×10-5 22885922 (PMID) Supplemental file
Hip circumfence, adjusted for BMI 3.6×10-4 25673412 (PMID) Supplemental file
Smoking behaviour, Age of onset 4.5×10-4 20418890 (PMID) Supplemental file