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Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 278

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
TECK cis Discovery rs6603134 19:8,106,521 G/A 0.40 997 0.353 0.044 4.1×10-15 1.180 1.9×10-14 2.4×10-9
TECK cis Replication rs6603134 19:8,106,521 A/G 0.41 337 -0.314 0.073 2×10-5 -1.180 2.1×10-5 0.002

 

Regional association plots

 

Boxplots and histograms for top associations

C-C motif chemokine 25 (TECK)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

C-C motif chemokine 25 (TECK)

Target (abbrv.) TECK
Target (full name) C-C motif chemokine 25
Somalogic ID (Sequence ID) SL003197 (2705-5_2)
Entrez Gene Symbol CCL25
UniProt ID O15444
UniProt Comment
  • Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Biomarker applications (based on IPA annotation)
  • disease progression
Reactome
  • Chemokine receptors bind chemokines
  • G alpha (i) signalling events

All locus annotations are based on the sentinel SNP (rs6603134) and 3 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
  • ELAVL1 ELAV like RNA binding protein 1

 

Results from other genome-wide association studies

Trait P Study Source
Gene expression of CCL25 in normal prepouch ileum 2.1×10-6 23474282 (PMID) GRASP2 eQTL
Autism 1.8×10-4 20663923 (PMID) GRASP2 nonQTL