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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 280

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
CNDP1 cis Discovery rs17817077 18:72,209,543 G/A 0.41 995 0.350 0.044 4.7×10-15 1.100 7.4×10-14 4.5×10-15
CNDP1 cis Replication rs17817077 18:72,209,543 G/A 0.37 337 0.263 0.068 1.4×10-4 1.130 1.2×10-4 2.2×10-4

 

Regional association plots

 

Boxplots and histograms for top associations

Beta-Ala-His dipeptidase (CNDP1)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Beta-Ala-His dipeptidase (CNDP1)

Target (abbrv.) CNDP1
Target (full name) Beta-Ala-His dipeptidase
Somalogic ID (Sequence ID) SL006694 (3604-6_4)
Entrez Gene Symbol CNDP1
UniProt ID Q96KN2
UniProt Comment
  • Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine.

All locus annotations are based on the sentinel SNP (rs17817077).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
  • CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family)
eQTL genes
  • CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family)

 

Results from other genome-wide association studies

Trait P Study Source
Gene expression of ZADH2 in T cells 2.2×10-5 19644074 (PMID) GRASP2 eQTL