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Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 285

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
MICA cis Discovery rs2523710 6:31,450,909 G/A 0.21 994 -0.425 0.054 6.5×10-15 -1.360 5.8×10-16 5.3×10-6
MICA cis Replication rs2523710 6:31,450,909 G/A 0.16 337 -0.142 0.097 0.146 -1.080 0.158 0.162

 

Regional association plots

MHC class I polypeptide-related sequence A (MICA)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

MHC class I polypeptide-related sequence A (MICA)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

MHC class I polypeptide-related sequence A (MICA)

Target (abbrv.) MICA
Target (full name) MHC class I polypeptide-related sequence A
Somalogic ID (Sequence ID) SL005199 (2730-58_2)
Entrez Gene Symbol MICA
UniProt ID Q29983
UniProt Comment
  • Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Biomarker applications (based on IPA annotation)
  • safety
Pathway Studio
  • Natural Killer Cell Activation
  • Natural Killer Cell Activation through C-type Lectin-like Receptors

All locus annotations are based on the sentinel SNP (rs2523710).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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eQTL genes
  • DXO decapping exoribonuclease
  • LST1 leukocyte specific transcript 1
  • HLA-B major histocompatibility complex, class I, B
  • AGER advanced glycosylation end product-specific receptor
  • MICB MHC class I polypeptide-related sequence B
  • PSMB8 proteasome (prosome, macropain) subunit, beta type, 8

 

Results from other genome-wide association studies

Trait P Study Source
Height 9.2×10-12 25282103 (PMID) Supplemental file
Rheumatoid arthritis 2.3×10-6 20453842 (PMID) GRASP2 nonQTL
Gene expression of LST1 [probe ILMN_22195] in osteoblasts with treatment interaction 2.8×10-5 21283786 (PMID) GRASP2 eQTL
Hip circumfence, adjusted for BMI 1.3×10-4 25673412 (PMID) Supplemental file
Total cholesterol 1.6×10-4 24097068 (PMID) Supplemental file