Locus 286

Top associations per target

Target	cis/trans	Study	SNP	SNP location	Maj/min allele	MAF	N	β_inv	se_inv	P_inv	fc_log	P_log	P_raw
Angiogenin	cis	Discovery	rs1888560	14:21,164,245	C/T	0.32	997	-0.345	0.044	6.7×10^-15	-1.080	1.3×10^-13	7.6×10^-11
Angiogenin	cis	Replication	rs1888560	14:21,164,245	G/A	0.30	337	-0.360	0.073	1.4×10^-6	-1.100	1.8×10^-6	2×10^-6

	inverse-normalized probe levels	log₂ transformed probe levels	raw probe levels
Discovery study
Replication study

Target (abbrv.)	Angiogenin
Target (full name)	Angiogenin
Somalogic ID (Sequence ID)	SL000003 (4874-3_1)
Entrez Gene Symbol	ANG
UniProt ID	P03950
UniProt Comment	Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Biomarker applications (based on IPA annotation)	response to therapy

All locus annotations are based on the sentinel SNP (rs1888560).
Download the detailed results of SNiPA's block annotation (PDF)

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Genes hit or close-by	RP11-903H12.3 RP11-903H12.5 RNASE4 ribonuclease, RNase A family, 4 ANG angiogenin, ribonuclease, RNase A family, 5
eQTL genes	RNASE4 ribonuclease, RNase A family, 4 RP11-903H12.5 ANG angiogenin, ribonuclease, RNase A family, 5

Trait	P	Study	Source
Gene expression of RNASE4 in blood	5.1×10^-6	21829388 (PMID)	GRASP2 eQTL