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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 30

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
HCC-4 cis Discovery rs33995560 17:34,303,771 T/C 0.08 997 -1.393 0.060 1.9×10-95 -1.780 1.3×10-129 1.2×10-92
HCC-4 cis Replication rs33995560 17:34,303,771 A/G 0.07 337 -0.790 0.131 4.9×10-9 -1.690 7.1×10-13 0.025

 

Regional association plots

 

Boxplots and histograms for top associations

C-C motif chemokine 16 (HCC-4)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

C-C motif chemokine 16 (HCC-4)

Target (abbrv.) HCC-4
Target (full name) C-C motif chemokine 16
Somalogic ID (Sequence ID) SL003300 (4913-78_1)
Entrez Gene Symbol CCL16
UniProt ID O15467
UniProt Comment
  • Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
Reactome
  • Chemokine receptors bind chemokines
  • G alpha (i) signalling events
Pathway Studio
  • CCR1 → STAT signaling
  • CCR2/5 → STAT signaling
  • CCR5 → TP53 signaling
  • Nociception-related CCR1 expression targets
  • Summarized nociception-related expression targets

All locus annotations are based on the sentinel SNP (rs33995560) and 6 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by

 

Results from other genome-wide association studies

Trait P Study Source
"Gene expression of CCL16 [transcript NM_004590, probe A_23_P207582] in liver" 2.3×10-11 21637794 (PMID) GRASP2 eQTL
O15467 protein abundance levels 2.5×10-11 22595970 (PMID) GRASP2 pQTL
cg22254135 (chr17:34309105) 9.7×10-7 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Gene expression of CCL16 in liver 2.8×10-6 18462017 (PMID) GRASP2 eQTL
cg22647738 (chr17:34304438) 1.8×10-5 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Alzheimer's disease 3.6×10-4 20061627 (PMID) GRASP2 nonQTL