Locus 303

Top associations per target

Target	cis/trans	Study	SNP	SNP location	Maj/min allele	MAF	N	β_inv	se_inv	P_inv	fc_log	P_log	P_raw
NPS-PLA2	cis	Discovery	rs17354650	1:20,390,322	C/T	0.28	996	0.356	0.046	1.7×10^-14	1.100	7.5×10^-14	1.1×10^-11
NPS-PLA2	cis	Replication	rs72661034	1:20,311,680	A/C	0.15	337	0.377	0.078	2×10^-6	1.190	3×10^-5	0.012

	inverse-normalized probe levels	log₂ transformed probe levels	raw probe levels
Discovery study
Replication study

Target (abbrv.)	NPS-PLA2
Target (full name)	Phospholipase A2, membrane associated
Somalogic ID (Sequence ID)	SL002528 (2692-74_2)
Entrez Gene Symbol	PLA2G2A
UniProt ID	P14555
UniProt Comment	Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Targeted by drugs (based on IPA annotation)	varespladib methyl varespladib indomethacin
Biomarker applications (based on IPA annotation)	efficacy prognosis safety
Wiki Pathways	Eicosanoid Synthesis MicroRNAs in cardiomyocyte hypertrophy
Pathway Interaction Database	Glypican 1 network
Reactome	Acyl chain remodelling of PC Acyl chain remodelling of PE Acyl chain remodelling of PG Acyl chain remodelling of PI Acyl chain remodelling of PS Synthesis of PA

All locus annotations are based on the sentinel SNP (rs17354650).
Download the detailed results of SNiPA's block annotation (PDF)

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Genes hit or close-by	PLA2G5 phospholipase A2, group V
eQTL genes	MRTO4 mRNA turnover 4 homolog (S. cerevisiae) OTUD3 OTU deubiquitinase 3

Trait	P	Study	Source
Serum ratio of (cysteine-glutathione disulfide)/(glycerate)	7.5×10^-5	21886157 (PMID)	GRASP2 metabQTL
Gene expression of PLA2G5 [probe 2323847] in brain cortex	1.9×10^-4	19222302 (PMID)	GRASP2 eQTL