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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 309

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
IL-15 Ra cis Discovery rs7097780 10:6,010,227 A/G 0.33 991 0.340 0.044 3.8×10-14 1.040 0.005 0.888
IL-15 Ra cis Replication rs8177654 10:6,015,197 A/G 0.33 337 0.063 0.060 0.292 1.010 0.404 0.547

 

Regional association plots

Interleukin-15 receptor subunit alpha (IL-15 Ra)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Interleukin-15 receptor subunit alpha (IL-15 Ra)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Interleukin-15 receptor subunit alpha (IL-15 Ra)

Target (abbrv.) IL-15 Ra
Target (full name) Interleukin-15 receptor subunit alpha
Somalogic ID (Sequence ID) SL004151 (3445-53_2)
Entrez Gene Symbol IL15RA
UniProt ID Q13261
UniProt Comment
  • High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK.
Biomarker applications (based on IPA annotation)
  • prognosis
Wiki Pathways
  • TCR Signaling Pathway
Pathway Studio
  • IL15R → NF-kB/NFATC signaling
  • IL15R → STAT signaling

All locus annotations are based on the sentinel SNP (rs7097780) and 14 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • IL15RA interleukin 15 receptor, alpha
Potentially regulated genes
eQTL genes
  • IL15RA interleukin 15 receptor, alpha

 

Results from other genome-wide association studies

Trait P Study Source
Gene expression of IL15RA in blood 4.7×10-8 21829388 (PMID) GRASP2 eQTL
Gene expression of IL15RA in peripheral blood monocytes 2.4×10-7 20502693 (PMID) GRASP2 eQTL