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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 313

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
MSP cis Discovery rs6442112 3:48,316,034 G/A 0.34 992 0.351 0.046 4.7×10-14 1.270 4.5×10-15 5.6×10-16
MSP cis Replication rs2889854 3:48,268,509 A/C 0.14 337 0.256 0.104 0.014 1.190 0.022 0.009

 

Regional association plots

Hepatocyte growth factor-like protein (MSP)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Hepatocyte growth factor-like protein (MSP)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Hepatocyte growth factor-like protein (MSP)

Target (abbrv.) MSP
Target (full name) Hepatocyte growth factor-like protein
Somalogic ID (Sequence ID) SL005202 (4407-10_1)
Entrez Gene Symbol MST1
UniProt ID P26927
UniProt Comment
  • Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts (via beta chain) with MST1R (via SEMA domain).
Pathway Interaction Database
  • FoxO family signaling
  • a6b1 and a6b4 Integrin signaling
  • amb2 Integrin signaling

All locus annotations are based on the sentinel SNP (rs6442112) and 2 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • CDC25A cell division cycle 25A
  • RNU7-128P RNA, U7 small nuclear 128 pseudogene
  • NDUFB1P1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1 pseudogene 1
  • CAMP cathelicidin antimicrobial peptide
  • ZNF589 zinc finger protein 589
Potentially regulated genes
  • UQCRC1 ubiquinol-cytochrome c reductase core protein I
  • SHISA5
  • MAP4 microtubule-associated protein 4
  • FBXW12 F-box and WD repeat domain containing 12
eQTL genes
  • SCAP SREBF chaperone
  • NCKIPSD NCK interacting protein with SH3 domain
  • MRPS18AP1 mitochondrial ribosomal protein S18A pseudogene 1
  • ZNF589 zinc finger protein 589
  • QRICH1 glutamine-rich 1
  • FCF1P2 FCF1 pseudogene 2
  • WDR6 WD repeat domain 6
  • NME6 NME/NM23 nucleoside diphosphate kinase 6
  • ARIH2OS ariadne homolog 2 opposite strand
  • AMT aminomethyltransferase
  • CDC25A cell division cycle 25A
  • KLHDC8B kelch domain containing 8B
  • TMA7 translation machinery associated 7 homolog (S. cerevisiae)
  • NICN1 nicolin 1

 

Results from other genome-wide association studies

Trait P Study Source
Gene expression of ZNF589 in blood 8×10-27 21829388 (PMID) GRASP2 eQTL
Gene expression of WDR6 in peripheral blood monocytes 2.8×10-25 20502693 (PMID) GRASP2 eQTL
Gene expression of NICN1 in peripheral blood monocytes 1.2×10-18 20502693 (PMID) GRASP2 eQTL
Gene expression of NCKIPSD in peripheral blood monocytes 8.4×10-15 20502693 (PMID) GRASP2 eQTL
Gene expression of AMT in peripheral blood monocytes 3.2×10-9 20502693 (PMID) GRASP2 eQTL
Gene expression of ZNF589 in peripheral blood monocytes 1.4×10-6 20502693 (PMID) GRASP2 eQTL
Gene expression of HIGD1A in peripheral blood monocytes 4.3×10-6 20502693 (PMID) GRASP2 eQTL
Gene expression of NEDD1 in peripheral blood monocytes 4.5×10-6 20502693 (PMID) GRASP2 eQTL
Gene expression of XRCC1 in peripheral blood monocytes 5.7×10-6 20502693 (PMID) GRASP2 eQTL
Gene expression of CREBZF in peripheral blood monocytes 5.9×10-6 20502693 (PMID) GRASP2 eQTL
Gene expression of ORMDL1 in peripheral blood monocytes 6.1×10-6 20502693 (PMID) GRASP2 eQTL
Gene expression of SKAP2 in peripheral blood monocytes 8.3×10-6 20502693 (PMID) GRASP2 eQTL
cg27340749 (chr3:48507361) 4.4×10-5 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Agreeableness (male) 6.9×10-5 18957941 (PMID) GRASP2 nonQTL
Serum ratio of (1-methylurate)/(pseudouridine) 1.4×10-4 21886157 (PMID) GRASP2 metabQTL
Gene expression of DHX30 [probe 212674_s_at] in prefrontal cortex 2.7×10-4 20351726 (PMID) GRASP2 eQTL
Waist circumfence, adjusted for BMI 3.5×10-4 25673412 (PMID) Supplemental file