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Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 32

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
IL-17 sR cis Discovery rs3827278 22:17,595,915 C/A 0.23 997 0.975 0.043 2×10-93 1.330 6×10-77 1.4×10-38
IL-17 sR cis Replication rs3827278 22:17,595,915 C/A 0.19 337 0.551 0.087 7.1×10-10 1.180 1×10-8 9.5×10-6

 

Regional association plots

Interleukin-17 receptor A (IL-17 sR)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Interleukin-17 receptor A (IL-17 sR)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Interleukin-17 receptor A (IL-17 sR)

Target (abbrv.) IL-17 sR
Target (full name) Interleukin-17 receptor A
Somalogic ID (Sequence ID) SL004850 (2992-59_2)
Entrez Gene Symbol IL17RA
UniProt ID Q96F46
UniProt Comment
  • Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).

All locus annotations are based on the sentinel SNP (rs3827278) and 2 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
  • IL17RA interleukin 17 receptor A
  • CECR6 cat eye syndrome chromosome region, candidate 6
eQTL genes

 

Results from other genome-wide association studies

Trait P Study Source
cg18137704 (chr22:17602657) 1.3×10-5 10.1101/033084 (DOI) BIOS QTL cis-meQTLs