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Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 334

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
TXD12 trans Discovery rs35365539 3:49,794,348 C/- 0.48 996 -0.320 0.043 1.4×10-13 -1.080 1.6×10-11 5.9×10-16
TXD12 trans Replication rs11130218 3:49,752,372 A/G 0.39 337 -0.221 0.083 0.008 -1.060 0.024 0.009

 

Regional association plots

Thioredoxin domain-containing protein 12 (TXD12)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Thioredoxin domain-containing protein 12 (TXD12)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Thioredoxin domain-containing protein 12 (TXD12)

Target (abbrv.) TXD12
Target (full name) Thioredoxin domain-containing protein 12
Somalogic ID (Sequence ID) SL016128 (4815-25_3)
Entrez Gene Symbol TXNDC12
UniProt ID O95881
UniProt Comment
  • Possesses significant protein thiol-disulfide oxidase activity.

All locus annotations are based on the sentinel SNP (rs35365539).
However, the sentinel SNP is not contained in SNiPA's database (1000 Genomes Project, phase 3 version 5, European population). Thus, no information about linked genes or further functional annotation is available.

 

Results from other genome-wide association studies


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No associations available.