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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 341

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
IL-18 Ra cis Discovery rs6725806 2:103,216,172 G/T 0.26 995 0.345 0.046 2.4×10-13 1.090 4.7×10-13 1.3×10-7
IL-18 Ra cis Replication rs6725806 2:103,216,172 C/A 0.30 337 0.124 0.065 0.058 1.050 0.035 0.056

 

Regional association plots

Interleukin-18 receptor 1 (IL-18 Ra)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Interleukin-18 receptor 1 (IL-18 Ra)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Interleukin-18 receptor 1 (IL-18 Ra)

Target (abbrv.) IL-18 Ra
Target (full name) Interleukin-18 receptor 1
Somalogic ID (Sequence ID) SL004152 (3446-7_2)
Entrez Gene Symbol IL18R1
UniProt ID Q13478
UniProt Comment
  • Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.
Pathway Interaction Database
  • IL12 signaling mediated by STAT4
  • IL12-mediated signaling events
  • IL23-mediated signaling events
Pathway Studio
  • Th1 Cell Differentiation

All locus annotations are based on the sentinel SNP (rs6725806).
However, the sentinel SNP is not contained in SNiPA's database (1000 Genomes Project, phase 3 version 5, European population). Thus, no information about linked genes or further functional annotation is available.

 

Results from other genome-wide association studies

Trait P Study Source
Serum concentration of 1,5-anhydroglucitol (1,5-AG) 5.9×10-5 21886157 (PMID) GRASP2 metabQTL