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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 347

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
Cripto cis Discovery rs939421 3:46,576,081 T/C 0.26 996 -0.363 0.049 4×10-13 -1.070 1.4×10-9 1.2×10-5
Cripto cis Replication rs939421 3:46,576,081 A/G 0.33 337 -0.217 0.082 0.008 -1.040 0.015 0.073

 

Regional association plots

Teratocarcinoma-derived growth factor 1 (Cripto)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Teratocarcinoma-derived growth factor 1 (Cripto)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Teratocarcinoma-derived growth factor 1 (Cripto)

Target (abbrv.) Cripto
Target (full name) Teratocarcinoma-derived growth factor 1
Somalogic ID (Sequence ID) SL005155 (2672-60_1)
Entrez Gene Symbol TDGF1
UniProt ID P13385
UniProt Comment
  • Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.
Biomarker applications (based on IPA annotation)
  • diagnosis

All locus annotations are based on the sentinel SNP (rs939421) and 2 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
  • LRRC2 leucine rich repeat containing 2
eQTL genes
  • TDGF1 teratocarcinoma-derived growth factor 1
  • LRRC2-AS1 LRRC2 antisense RNA 1
  • LRRC2 leucine rich repeat containing 2

 

Results from other genome-wide association studies


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No associations available.