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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 351

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
sICAM-5 cis Discovery rs1051738 19:10,577,843 C/A 0.17 995 -0.409 0.056 4.6×10-13 -1.110 1.4×10-12 4.5×10-10
sICAM-5 cis Replication rs35164067 19:10,525,181 G/A 0.27 337 -0.168 0.077 0.03 -1.050 0.028 0.022

 

Regional association plots

Intercellular adhesion molecule 5 (sICAM-5)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Intercellular adhesion molecule 5 (sICAM-5)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Intercellular adhesion molecule 5 (sICAM-5)

Target (abbrv.) sICAM-5
Target (full name) Intercellular adhesion molecule 5
Somalogic ID (Sequence ID) SL005169 (5124-69_3)
Entrez Gene Symbol ICAM5
UniProt ID Q9UMF0
UniProt Comment
  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

All locus annotations are based on the sentinel SNP (rs1051738) and 21 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
  • PDE4A phosphodiesterase 4A, cAMP-specific
Potentially regulated genes
  • ZGLP1 zinc finger, GATA-like protein 1
  • TYK2 tyrosine kinase 2
  • TYK2
  • PPAN-P2RY11 PPAN-P2RY11 readthrough
  • KRI1 KRI1 homolog (S. cerevisiae)
  • PPAN peter pan homolog (Drosophila)
  • P2RY11 purinergic receptor P2Y, G-protein coupled, 11
eQTL genes
  • TYK2 tyrosine kinase 2
  • S1PR5 sphingosine-1-phosphate receptor 5
  • KEAP1 kelch-like ECH-associated protein 1
  • ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
  • SLC44A2 solute carrier family 44 (choline transporter), member 2

 

Results from other genome-wide association studies

Trait P Study Source
cg24189696 (chr19:10585842) 1.3×10-241 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg20036207 (chr19:10397007) 1.8×10-13 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Soluble intercellular adhesion molecule 1 (ICAM-1) 1.6×10-12 21533024 (PMID) GRASP2 nonQTL
Crohn's disease 2.8×10-8 Supplemental file
Inflammatory bowel disease 9.7×10-8 Supplemental file
Gene expression of ICAM4 in peripheral blood monocytes 2.1×10-6 20502693 (PMID) GRASP2 eQTL
Type 1 diabetes 1.3×10-5 21980299 (PMID) GRASP2 nonQTL
Irritible bowel syndrome 1.1×10-4 18587394 (PMID) GRASP2 nonQTL
Gene expression of S1PR5 in blood 3.7×10-4 21829388 (PMID) GRASP2 eQTL