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Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 359

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
PARC cis Discovery rs35871176 17:34,375,832 C/T 0.48 997 -0.308 0.042 7.3×10-13 -1.140 6.9×10-13 1.5×10-10
PARC cis Replication rs35871176 17:34,375,832 G/A 0.48 337 -0.222 0.070 0.002 -1.090 0.002 0.011

 

Regional association plots

 

Boxplots and histograms for top associations

C-C motif chemokine 18 (PARC)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

C-C motif chemokine 18 (PARC)

Target (abbrv.) PARC
Target (full name) C-C motif chemokine 18
Somalogic ID (Sequence ID) SL003323 (3044-3_2)
Entrez Gene Symbol CCL18
UniProt ID P55774
UniProt Comment
  • Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.
Biomarker applications (based on IPA annotation)
  • efficacy
  • safety

All locus annotations are based on the sentinel SNP (rs35871176) and 3 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

There are no genes linked to the sentinel variant or to one of its proxies in linkage disequilibrium.

 

Results from other genome-wide association studies


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No associations available.