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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 366

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
MIP-5 cis Discovery rs2056492 17:34,318,565 A/C 0.02 996 1.271 0.176 9.9×10-13 1.530 2.6×10-15 4×10-13

 

Regional association plots

 

Boxplots and histograms for top associations

C-C motif chemokine 15 (MIP-5)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

C-C motif chemokine 15 (MIP-5)

Target (abbrv.) MIP-5
Target (full name) C-C motif chemokine 15
Somalogic ID (Sequence ID) SL003190 (3509-1_1)
Entrez Gene Symbol CCL15
UniProt ID Q16663
UniProt Comment
  • Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.
Pathway Studio
  • CCR1 → STAT signaling
  • Nociception-related CCR1 expression targets
  • Summarized nociception-related expression targets

All locus annotations are based on the sentinel SNP (rs2056492) and 9 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by

 

Results from other genome-wide association studies


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No associations available.