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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 370

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
KI2L4 cis Discovery rs7259090 19:55,392,646 G/A 0.17 997 0.413 0.057 1.3×10-12 1.110 2.4×10-7 0.652

 

Regional association plots

Killer cell immunoglobulin-like receptor 2DL4 (KI2L4)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Killer cell immunoglobulin-like receptor 2DL4 (KI2L4)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

Killer cell immunoglobulin-like receptor 2DL4 (KI2L4)

Target (abbrv.) KI2L4
Target (full name) Killer cell immunoglobulin-like receptor 2DL4
Somalogic ID (Sequence ID) SL012698 (5095-21_3)
Entrez Gene Symbol KIR2DL4
UniProt ID Q99706
UniProt Comment
  • Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.
Reactome
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Pathway Studio
  • Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors

All locus annotations are based on the sentinel SNP (rs7259090).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
  • FCAR Fc fragment of IgA, receptor for

 

Results from other genome-wide association studies

Trait P Study Source
cg14550066 (chr19:55417524) 8×10-8 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
cg17804112 (chr19:55417520) 4.8×10-6 10.1101/033084 (DOI) BIOS QTL cis-meQTLs