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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 376

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
MSP cis Discovery rs9869826 3:50,998,816 T/C 0.09 987 -0.542 0.076 1.8×10-12 -1.420 3.9×10-12 2.1×10-15
MSP cis Replication rs1540293 3:50,463,935 G/A 0.09 337 -0.131 0.135 0.333 -1.150 0.147 0.133

 

Regional association plots

Hepatocyte growth factor-like protein (MSP)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Hepatocyte growth factor-like protein (MSP)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Hepatocyte growth factor-like protein (MSP)

Target (abbrv.) MSP
Target (full name) Hepatocyte growth factor-like protein
Somalogic ID (Sequence ID) SL005202 (4407-10_1)
Entrez Gene Symbol MST1
UniProt ID P26927
UniProt Comment
  • Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts (via beta chain) with MST1R (via SEMA domain).
Pathway Interaction Database
  • FoxO family signaling
  • a6b1 and a6b4 Integrin signaling
  • amb2 Integrin signaling

All locus annotations are based on the sentinel SNP (rs9869826) and 12 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
  • MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
  • DOCK3 dedicator of cytokinesis 3
  • ST13P14 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 14
eQTL genes
  • HYAL3 hyaluronoglucosaminidase 3
  • NAT6 N-acetyltransferase 6 (GCN5-related)
  • MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
  • WDR6 WD repeat domain 6
  • C3orf62 chromosome 3 open reading frame 62
  • USP4 ubiquitin specific peptidase 4 (proto-oncogene)
  • RPL29 ribosomal protein L29

 

Results from other genome-wide association studies

Trait P Study Source
Gene expression of USP4 in peripheral blood monocytes 4.5×10-17 20502693 (PMID) GRASP2 eQTL
Gene expression of HYAL3 in peripheral blood monocytes 8.7×10-10 20502693 (PMID) GRASP2 eQTL
Gene expression of WDR6 in peripheral blood monocytes 1.4×10-9 20502693 (PMID) GRASP2 eQTL
Gene expression of MAPKAPK3 in peripheral blood monocytes 2.2×10-7 20502693 (PMID) GRASP2 eQTL
Serum ratio of (2-methylbutyroylcarnitine)/(docosapentaenoate (n3 DPA; 22:5n3)) 5.3×10-7 21886157 (PMID) GRASP2 metabQTL
Weight loss after gastric bypass surgery 6.9×10-5 23633212 (PMID) GRASP2 nonQTL