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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 377

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
TARC trans Discovery rs983545 3:16,959,652 G/A 0.35 995 0.320 0.045 2.3×10-12 1.090 7.6×10-12 1.4×10-8
TARC trans Replication rs9882937 3:16,959,532 G/A 0.33 337 0.093 0.067 0.168 1.050 0.245 0.642

 

Regional association plots

 

Boxplots and histograms for top associations

C-C motif chemokine 17 (TARC)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

C-C motif chemokine 17 (TARC)

Target (abbrv.) TARC
Target (full name) C-C motif chemokine 17
Somalogic ID (Sequence ID) SL003196 (3519-3_2)
Entrez Gene Symbol CCL17
UniProt ID Q92583
UniProt Comment
  • Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
Pathway Interaction Database
  • IL4-mediated signaling events
Reactome
  • Chemokine receptors bind chemokines

All locus annotations are based on the sentinel SNP (rs983545) and 17 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by
Potentially regulated genes
  • PLCL2 phospholipase C-like 2
eQTL genes
  • PLCL2 phospholipase C-like 2

 

Results from other genome-wide association studies

Trait P Study Source
Gene expression of PLCL2 in blood 2.7×10-13 21829388 (PMID) GRASP2 eQTL
Gene expression of PLCL2 in peripheral blood monocytes 4.7×10-10 20502693 (PMID) GRASP2 eQTL
Primary biliary cirrhosis 2×10-8 21399635 (PMID) GWAS Catalog via SNiPA
caproate (6:0) 8.6×10-6 24816252 (PMID) gwas.eu via SNiPA
Serum ratio of (ADpSGEGDFXAEGGGVR*)/(quinate) 9.1×10-6 21886157 (PMID) GRASP2 metabQTL
cg20942097 (chr3:16957585) 1×10-5 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
Schizophrenia 6.4×10-5 25056061 (PMID) Supplemental file
Educational attainment, Education years 8.3×10-5 23722424 (PMID) Supplemental file
Years of education 8.3×10-5 23722424 (PMID) GRASP2 nonQTL