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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 382

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
BST1 cis Discovery rs1110258 4:15,742,716 A/G 0.25 997 0.359 0.051 2.7×10-12 1.180 2.7×10-11 3.6×10-12
BST1 cis Replication rs62290623 4:15,752,676 G/A 0.20 337 0.238 0.077 0.002 1.090 0.114 0.002

 

Regional association plots

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (BST1)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (BST1)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (BST1)

Target (abbrv.) BST1
Target (full name) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
Somalogic ID (Sequence ID) SL008644 (4535-50_2)
Entrez Gene Symbol BST1
UniProt ID Q10588
UniProt Comment
  • Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

All locus annotations are based on the sentinel SNP (rs1110258) and 1 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by

 

Results from other genome-wide association studies


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No associations available.