HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Home
Ideogram
Loci
Network view
Proteome annotation
Help
Locus annotations

Locus 395

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
MIP-5 cis Discovery rs2075746 17:34,325,532 C/T 0.44 992 -0.297 0.042 4.3×10-12 -1.100 3.6×10-14 3.8×10-14
MIP-5 cis Replication rs2075746 17:34,325,532 G/A 0.34 337 -0.414 0.068 4.1×10-9 -1.170 1.1×10-9 8×10-9

 

Regional association plots

 

Boxplots and histograms for top associations

C-C motif chemokine 15 (MIP-5)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

C-C motif chemokine 15 (MIP-5)

Target (abbrv.) MIP-5
Target (full name) C-C motif chemokine 15
Somalogic ID (Sequence ID) SL003190 (3509-1_1)
Entrez Gene Symbol CCL15
UniProt ID Q16663
UniProt Comment
  • Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.
Pathway Studio
  • CCR1 → STAT signaling
  • Nociception-related CCR1 expression targets
  • Summarized nociception-related expression targets

All locus annotations are based on the sentinel SNP (rs2075746).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


Warning: count(): Parameter must be an array or an object that implements Countable in /var/www/html/pGWAS/locuscard.php on line 327

Warning: count(): Parameter must be an array or an object that implements Countable in /var/www/html/pGWAS/locuscard.php on line 343
Genes hit or close-by

 

Results from other genome-wide association studies


Warning: count(): Parameter must be an array or an object that implements Countable in /var/www/html/pGWAS/locuscard.php on line 365

No associations available.