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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 40

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
KYNU cis Discovery rs9013 2:143,798,189 A/G 0.16 997 -1.045 0.050 1×10-81 -1.350 9.8×10-64 1.1×10-10
KYNU cis Replication rs3768844 2:143,796,694 A/G 0.17 337 -0.686 0.073 8×10-19 -1.260 3.9×10-17 5.4×10-12

 

Regional association plots

 

Boxplots and histograms for top associations

Kynureninase (KYNU)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Kynureninase (KYNU)

Target (abbrv.) KYNU
Target (full name) Kynureninase
Somalogic ID (Sequence ID) SL013969 (4559-64_2)
Entrez Gene Symbol KYNU
UniProt ID Q16719
UniProt Comment
  • Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.

All locus annotations are based on the sentinel SNP (rs9013) and 27 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by

 

Results from other genome-wide association studies

Trait P Study Source
Gene expression of KYNU in blood 6.9×10-16 21829388 (PMID) GRASP2 eQTL
Gene expression of KYNU in peripheral blood monocytes 1.3×10-9 20502693 (PMID) GRASP2 eQTL
Gene expression of ARHGAP15 in peripheral blood monocytes 2.9×10-7 20502693 (PMID) GRASP2 eQTL
Gene expression of ARID3A in peripheral blood monocytes 3.3×10-6 20502693 (PMID) GRASP2 eQTL
Crohn's disease, combined control dataset, gender differentiated 1.4×10-5 17554300 (PMID) GRASP2 nonQTL
Serum ratio of (leucylleucine)/(phenylacetate) 2.9×10-4 21886157 (PMID) GRASP2 metabQTL
Serum ratio of (caffeine)/(theophylline) 3.5×10-4 21886157 (PMID) GRASP2 metabQTL