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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 402

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
SPARCL1 cis Discovery rs1462372 4:88,478,750 T/C 0.33 997 0.321 0.046 6.3×10-12 1.060 1.4×10-11 1.5×10-11
SPARCL1 cis Replication rs6847175 4:88,481,387 A/G 0.45 337 0.340 0.066 4×10-7 1.090 2.4×10-7 1.5×10-6

 

Regional association plots

 

Boxplots and histograms for top associations

SPARC-like protein 1 (SPARCL1)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

SPARC-like protein 1 (SPARCL1)

Target (abbrv.) SPARCL1
Target (full name) SPARC-like protein 1
Somalogic ID (Sequence ID) SL005488 (4467-49_2)
Entrez Gene Symbol SPARCL1
UniProt ID Q14515
UniProt Comment
  • Secreted
Biomarker applications (based on IPA annotation)
  • disease progression

All locus annotations are based on the sentinel SNP (rs1462372) and 2 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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eQTL genes
  • SPARCL1 SPARC-like 1 (hevin)
  • HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13

 

Results from other genome-wide association studies

Trait P Study Source
stearidonate (18:4n3) 1.9×10-5 24816252 (PMID) gwas.eu via SNiPA