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Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 409

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
IL-1 R4 cis Discovery rs3917254 2:102,776,518 G/A 0.10 994 -0.440 0.064 1.2×10-11 -1.200 3.8×10-12 1.6×10-6
IL-1 R4 cis Replication rs3917254 2:102,776,518 G/A 0.19 337 -0.174 0.086 0.043 -1.080 0.039 0.146

 

Regional association plots

Interleukin-1 receptor-like 1 (IL-1 R4)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Interleukin-1 receptor-like 1 (IL-1 R4)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Interleukin-1 receptor-like 1 (IL-1 R4)

Target (abbrv.) IL-1 R4
Target (full name) Interleukin-1 receptor-like 1
Somalogic ID (Sequence ID) SL004146 (4234-8_2)
Entrez Gene Symbol IL1RL1
UniProt ID Q01638
UniProt Comment
  • Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.

All locus annotations are based on the sentinel SNP (rs3917254).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
  • IL1R1 interleukin 1 receptor, type I

 

Results from other genome-wide association studies

Trait P Study Source
Serum ratio of (laurate (12:0))/(N-acetylalanine) 2.8×10-6 21886157 (PMID) GRASP2 metabQTL
Asthma 3.8×10-4 20159242 (PMID) GRASP2 nonQTL