Target | cis/trans | Study | SNP | SNP location | Maj/min allele | MAF | N | βinv | seinv | Pinv | fclog | Plog | Praw |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Caspase-3 | cis | Discovery | rs870825 | 4:185,588,045 | A/G | 0.16 | 995 | -0.396 | 0.058 | 1.8×10-11 | -1.140 | 3.1×10-10 | 8.4×10-6 |
Caspase-3 | cis | Replication | rs72689273 | 4:185,592,750 | G/A | 0.14 | 337 | -0.152 | 0.062 | 0.014 | -1.130 | 0.022 | 0.026 |
Target (abbrv.) | Caspase-3 |
Target (full name) | Caspase-3 |
Somalogic ID (Sequence ID) | SL003711 (3593-72_3) |
Entrez Gene Symbol | CASP3 |
UniProt ID | P42574 |
UniProt Comment |
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Targeted by drugs (based on IPA annotation) |
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Biomarker applications (based on IPA annotation) |
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Wiki Pathways |
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Pathway Interaction Database |
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Reactome |
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Pathway Studio |
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All locus annotations are based on the sentinel SNP (rs870825) and 88 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)
Genes hit or close-by | |
Potentially regulated genes |
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eQTL genes |
Trait | P | Study | Source |
---|---|---|---|
Gene expression of CASP3 in blood | 1.5×10-12 | 21829388 (PMID) | GRASP2 eQTL |
cg22905866 (chr4:185468801) | 4.8×10-9 | 10.1101/033084 (DOI) | BIOS QTL cis-meQTLs |
PC aa C40:2 / PC aa C40:5 | 6.5×10-7 | 20037589 (PMID) | GRASP2 metabQTL |
Gene expression of LRRC6 in peripheral blood monocytes | 7.4×10-6 | 20502693 (PMID) | GRASP2 eQTL |
Gene expression of ISLR2 in peripheral blood monocytes | 7.7×10-6 | 20502693 (PMID) | GRASP2 eQTL |
Serum ratio of (cysteine)/(N-acetylthreonine) | 3.5×10-5 | 21886157 (PMID) | GRASP2 metabQTL |
Serum concentration of erythrose | 1.8×10-4 | 21886157 (PMID) | GRASP2 metabQTL |
High-grade glioma | 4.3×10-4 | 19578366 (PMID) | GRASP2 nonQTL |
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