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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 420

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
Angiotensinogen cis Discovery rs2493151 1:230,878,561 G/A 0.23 994 0.335 0.049 2.2×10-11 1.080 6.3×10-11 7×10-10
Angiotensinogen cis Replication rs1317181 1:230,873,488 C/A 0.48 337 0.146 0.067 0.03 1.030 0.092 0.186

 

Regional association plots

 

Boxplots and histograms for top associations

Angiotensinogen

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Angiotensinogen

Target (abbrv.) Angiotensinogen
Target (full name) Angiotensinogen
Somalogic ID (Sequence ID) SL000271 (3484-60_2)
Entrez Gene Symbol AGT
UniProt ID P01019
UniProt Comment
  • Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
Biomarker applications (based on IPA annotation)
  • efficacy
Wiki Pathways
  • ACE Inhibitor Pathway
  • Adipogenesis
  • IL-6 signaling pathway
  • MicroRNAs in cardiomyocyte hypertrophy
  • Monoamine Transport
  • Physiological and Pathological Hypertrophy of the Heart
Pathway Interaction Database
  • AP-1 transcription factor network
  • Signaling events mediated by PRL
Reactome
  • G alpha (i) signalling events
  • G alpha (q) signalling events
  • Metabolism of Angiotensinogen to Angiotensins
  • PPARA activates gene expression
  • Peptide ligand-binding receptors
Pathway Studio
  • AngiotensinR → CREB/ELK-SRF/TP53 signaling
  • AngiotensinR → STAT signaling

All locus annotations are based on the sentinel SNP (rs2493151) and 2 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by

 

Results from other genome-wide association studies

Trait P Study Source
Serum ratio of (1-arachidonoylglycerophosphocholine*)/(4-acetamidobutanoate) 3.7×10-5 21886157 (PMID) GRASP2 metabQTL