Locus 446

Top associations per target

Target	cis/trans	Study	SNP	SNP location	Maj/min allele	MAF	N	β_inv	se_inv	P_inv	fc_log	P_log	P_raw
ART	cis	Discovery	rs8051517	16:68,428,089	T/C	0.06	996	0.567	0.086	6.9×10^-11	1.150	2×10^-10	4.1×10^-8
ART	cis	Replication	rs74024437	16:68,326,247	G/A	0.07	337	0.264	0.115	0.023	1.100	0.018	0.038

	inverse-normalized probe levels	log₂ transformed probe levels	raw probe levels
Discovery study
Replication study

Target (abbrv.)	ART
Target (full name)	Agouti-related protein
Somalogic ID (Sequence ID)	SL006924 (2813-11_2)
Entrez Gene Symbol	AGRP
UniProt ID	O00253
UniProt Comment	Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Biomarker applications (based on IPA annotation)	unspecified application
Pathway Interaction Database	Syndecan-3-mediated signaling events

All locus annotations are based on the sentinel SNP (rs8051517).
Download the detailed results of SNiPA's block annotation (PDF)

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Genes hit or close-by	SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
eQTL genes	TRADD TNFRSF1A-associated via death domain DUS2 dihydrouridine synthase 2 ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1

Trait	P	Study	Source
Gene expression of DUS2L in peripheral blood monocytes	1.8×10^-13	20502693 (PMID)	GRASP2 eQTL
Gene expression of ATP6V0D1 in peripheral blood monocytes	1.7×10^-12	20502693 (PMID)	GRASP2 eQTL
Gene expression of DCDC5 in peripheral blood monocytes	7×10^-8	20502693 (PMID)	GRASP2 eQTL
Gene expression of TRADD in peripheral blood monocytes	1.2×10^-6	20502693 (PMID)	GRASP2 eQTL
Gene expression of MRPL11 in peripheral blood monocytes	2.5×10^-6	20502693 (PMID)	GRASP2 eQTL
Gene expression of ECHS1 in peripheral blood monocytes	3.7×10^-6	20502693 (PMID)	GRASP2 eQTL
Gene expression of ZDHHC1 in peripheral blood monocytes	5.4×10^-6	20502693 (PMID)	GRASP2 eQTL
Gene expression of RPS3 in peripheral blood monocytes	6.1×10^-6	20502693 (PMID)	GRASP2 eQTL
Gene expression of MSRB2 in peripheral blood monocytes	7.8×10^-6	20502693 (PMID)	GRASP2 eQTL
Height	5.8×10^-5	25282103 (PMID)	Supplemental file