Locus 451

GWAS results
Target annotations
Locus annotations
Network

Top associations per target

Target	cis/trans	Study	SNP	SNP location	Maj/min allele	MAF	N	β_inv	se_inv	P_inv	fc_log	P_log	P_raw
Kallistatin	cis	Discovery	rs10135681	14:95,007,744	T/C	0.40	997	0.277	0.042	8.4×10^-11	1.040	2.6×10^-10	8.1×10^-11
Kallistatin	cis	Replication	rs10135681	14:95,007,744	A/G	0.38	337	0.007	0.075	0.929	1.000	0.976	0.986

Regional association plots

Kallistatin

Download the association data used to generate this plot

Boxplots and histograms for top associations

Kallistatin

	inverse-normalized probe levels	log₂ transformed probe levels	raw probe levels
Discovery study
Replication study

Kallistatin

Target (abbrv.)	Kallistatin
Target (full name)	Kallistatin
Somalogic ID (Sequence ID)	SL004876 (3449-58_2)
Entrez Gene Symbol	SERPINA4
UniProt ID	P29622
UniProt Comment	Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.

All locus annotations are based on the sentinel SNP (rs10135681).
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

There are no genes linked to the sentinel variant or to one of its proxies in linkage disequilibrium.

Results from other genome-wide association studies

Trait	P	Study	Source
Height	2.7×10^-4	25282103 (PMID)	Supplemental file