Top associations per target

 

Regional association plots

 

Boxplots and histograms for top associations

All locus annotations are based on the sentinel SNP (rs1622406) and 17 proxy variant(s) that is/are in linkage disequilibrium r² ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.

Linked genes

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Genes hit or close-by

USP8P1 ubiquitin specific peptidase 8 pseudogene 1 HLA-C major histocompatibility complex, class I, C RPL3P2 ribosomal protein L3 pseudogene 2 HLA-B major histocompatibility complex, class I, B XXbac-BPG248L24.12 MIR6891 microRNA 6891 PPIAP9 peptidylprolyl isomerase A (cyclophilin A) pseudogene 9 MICB MHC class I polypeptide-related sequence B XXbac-BPG16N22.5

Potentially regulated genes

DDX39B LTA GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa MICB MICB MICB HLA-B HSPA1L XXbac-BPG248L24.10 HLA-B major histocompatibility complex, class I, B HLA-B HLA-B GTF2H4 GTF2H4 HSPA1L MICB XXbac-BPG248L24.10 XXbac-BPG248L24.10 HSPA1L heat shock 70kDa protein 1-like DDX39B GTF2H4 LTA LTA XXbac-BPG248L24.10 GTF2H4 DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B DDX39B XXbac-BPG181B23.6 HLA-B DDX39B XXbac-BPG248L24.10 MICB GTF2H4 DDX39B MICB XXbac-BPG248L24.10 HLA-B HSPA1L MICB MICB MHC class I polypeptide-related sequence B DDX39B DDX39B HSPA1L XXbac-BPG248L24.10 LTA LTA LTA LTA lymphotoxin alpha LY6G5B HCG27 MICA HLA-C major histocompatibility complex, class I, C LY6G5B HLA-C VARS TNF TNF HCG27 NCR3 ATP6V1G2 HLA-C NCR3 XXbac-BPG248L24.12 LY6G5B lymphocyte antigen 6 complex, locus G5B LY6G5B ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 VARS valyl-tRNA synthetase GPANK1 TNF GPANK1 NCR3 NCR3 MICA MHC class I polypeptide-related sequence A HCP5 GPANK1 PRRC2A HLA-C MICA VARS ATP6V1G2 HCP5 MICA XXbac-BPG299F13.15 GPANK1 GPANK1 HLA-C NCR3 natural cytotoxicity triggering receptor 3 PRRC2A HLA-C HCG27 TNF NCR3 VARS HCG27 HLA complex group 27 (non-protein coding) HLA-C PRRC2A TNF ATP6V1G2 TNF tumor necrosis factor ATP6V1G2 HCP5 LY6G5B VARS PRRC2A VARS NCR3 NCR3 VARS HCG27 TNF ATP6V1G2 PRRC2A proline-rich coiled-coil 2A LY6G5B ATP6V1G2 TNF HCP5 HLA complex P5 (non-protein coding) LY6G5B PRRC2A HCG27 HCG27 MICA GPANK1 G patch domain and ankyrin repeats 1 PRRC2A GPANK1

 

Results from other genome-wide association studies

Trait	P	Study	Source
Height	1.2×10-8	25282103 (PMID)	Supplemental file
Crohn's disease	1×10-5		Supplemental file
Hip circumfence, adjusted for BMI	1.7×10-5	25673412 (PMID)	Supplemental file
Rheumatoid arthritis	2.2×10-5	20453842 (PMID)	GRASP2 nonQTL