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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 66

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
TXD12 trans Discovery rs35395347 3:49,334,797 A/G 0.07 996 -1.287 0.077 7.8×10-55 -1.410 3×10-62 9.9×10-45

 

Regional association plots

Thioredoxin domain-containing protein 12 (TXD12)

Download the association data used to generate this plot

 

Boxplots and histograms for top associations

Thioredoxin domain-containing protein 12 (TXD12)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study

Thioredoxin domain-containing protein 12 (TXD12)

Target (abbrv.) TXD12
Target (full name) Thioredoxin domain-containing protein 12
Somalogic ID (Sequence ID) SL016128 (4815-25_3)
Entrez Gene Symbol TXNDC12
UniProt ID O95881
UniProt Comment
  • Possesses significant protein thiol-disulfide oxidase activity.

All locus annotations are based on the sentinel SNP (rs35395347) and 4 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
  • CCDC36 coiled-coil domain containing 36
  • USP4 ubiquitin specific peptidase 4 (proto-oncogene)
eQTL genes
  • MST1 macrophage stimulating 1
  • MRPS18AP1 mitochondrial ribosomal protein S18A pseudogene 1
  • ZNF589 zinc finger protein 589
  • APEH acylaminoacyl-peptide hydrolase
  • NICN1 nicolin 1
  • AMT aminomethyltransferase

 

Results from other genome-wide association studies

Trait P Study Source
Gene expression of USP4 in normal prepouch ileum 4.2×10-4 23474282 (PMID) GRASP2 eQTL