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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

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Locus annotations

Locus 75

Top associations per target

Target cis/​trans Study SNP SNP location Maj/​min allele MAF N βinv seinv Pinv fclog Plog Praw
kallikrein 12 cis Discovery rs8103941 19:51,546,852 A/G 0.25 996 0.739 0.047 5.3×10-50 1.230 2.7×10-47 1.7×10-25
kallikrein 12 cis Replication rs8111766 19:51,540,228 A/C 0.15 337 0.470 0.103 6.6×10-6 1.170 2.9×10-6 3.6×10-6

 

Regional association plots

 

Boxplots and histograms for top associations

Kallikrein-12 (kallikrein 12)

inverse-normalized probe levels log2 transformed probe levels raw probe levels
Discovery study
Replication study

Kallikrein-12 (kallikrein 12)

Target (abbrv.) kallikrein 12
Target (full name) Kallikrein-12
Somalogic ID (Sequence ID) SL003916 (3199-54_2)
Entrez Gene Symbol KLK12
UniProt ID Q9UKR0
UniProt Comment
  • Secreted

All locus annotations are based on the sentinel SNP (rs8103941) and 16 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes


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Genes hit or close-by
eQTL genes

 

Results from other genome-wide association studies

Trait P Study Source
cg15652303 (chr19:51534112) 2.8×10-8 10.1101/033084 (DOI) BIOS QTL cis-meQTLs
dihomo-linolenate (20:3n3 or n6) 7×10-5 24816252 (PMID) gwas.eu via SNiPA