Locus 83

Top associations per target

Target	cis/trans	Study	SNP	SNP location	Maj/min allele	MAF	N	β_inv	se_inv	P_inv	fc_log	P_log	P_raw
ASAHL	cis	Discovery	rs4859571	4:76,857,309	C/T	0.24	997	-0.705	0.047	1.1×10^-46	-1.360	3.3×10^-44	7×10^-25
ASAHL	cis	Replication	rs2242470	4:76,878,688	G/A	0.17	337	-0.523	0.088	6.9×10^-9	-1.280	2.6×10^-8	9.1×10^-6

Regional association plots

N-acylethanolamine-hydrolyzing acid amidase (ASAHL)

Download the association data used to generate this plot

Boxplots and histograms for top associations

N-acylethanolamine-hydrolyzing acid amidase (ASAHL)

	inverse-normalized probe levels	log₂ transformed probe levels	raw probe levels
Discovery study
Replication study

N-acylethanolamine-hydrolyzing acid amidase (ASAHL)

Target (abbrv.)	ASAHL
Target (full name)	N-acylethanolamine-hydrolyzing acid amidase
Somalogic ID (Sequence ID)	SL008611 (3173-49_2)
Entrez Gene Symbol	NAAA
UniProt ID	Q02083
UniProt Comment	Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.

All locus annotations are based on the sentinel SNP (rs4859571) and 61 proxy variant(s) that is/are in linkage disequilibrium r² ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)

Linked genes

Genes hit or close-by	NAAA N-acylethanolamine acid amidase SDAD1 SDA1 domain containing 1 AC110615.1 RP11-630D6.5 AC112719.2 CXCL9 chemokine (C-X-C motif) ligand 9 ART3 ADP-ribosyltransferase 3 CXCL11 chemokine (C-X-C motif) ligand 11 RP11-630D6.1
Potentially regulated genes	NAAA N-acylethanolamine acid amidase CCDC158 coiled-coil domain containing 158 NUP54 nucleoporin 54kDa USO1 USO1 vesicle transport factor
eQTL genes	ART3 ADP-ribosyltransferase 3 NAAA N-acylethanolamine acid amidase CXCL10 chemokine (C-X-C motif) ligand 10 CXCL11 chemokine (C-X-C motif) ligand 11 CXCL9 chemokine (C-X-C motif) ligand 9 SCARB2 scavenger receptor class B, member 2

Results from other genome-wide association studies

Show entries

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Trait	P	Study	Source
Gene expression of ASAHL in peripheral blood monocytes	9.7×10^-31	20502693 (PMID)	GRASP2 eQTL
Gene expression of NAAA in blood	8.1×10^-29	21829388 (PMID)	GRASP2 eQTL
Gene expression of NAAA [probe 214765_s_at] in lymphoblastoid cell lines	2.1×10^-22	17873877 (PMID)	GRASP2 eQTL
Gene expression of NAAA [probe 227135_at] in lymphoblastoid cell lines	2.5×10^-21	17873877 (PMID)	GRASP2 eQTL
Gene expression of ASAHL in lymphoblastoid cell lines	2×10^-20	17873877 (PMID)	GRASP2 eQTL
Gene expression of CXCL10 [probe 204533_at] in lymphoblastoid cell lines	2.4×10^-18	17873877 (PMID)	GRASP2 eQTL
Gene expression of CXCL10 in lymphoblastoid cell lines	2.7×10^-17	17873877 (PMID)	GRASP2 eQTL
Gene expression of NAAA in liver	2.9×10^-15	21637794 (PMID)	GRASP2 eQTL
Gene expression of NAAA (probeID ILMN_2391512) in cerebellum in Alzheimer's disease cases and controls	2.1×10^-12	22685416 (PMID)	GRASP2 eQTL
Gene expression of ASAHL in liver	2.9×10^-11	18462017 (PMID)	GRASP2 eQTL

Showing 1 to 10 of 38 entries

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Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Locus 83

Top associations per target

Regional association plots

N-acylethanolamine-hydrolyzing acid amidase (ASAHL)

Boxplots and histograms for top associations

N-acylethanolamine-hydrolyzing acid amidase (ASAHL)

N-acylethanolamine-hydrolyzing acid amidase (ASAHL)

Linked genes

Results from other genome-wide association studies