Target | cis/trans | Study | SNP | SNP location | Maj/min allele | MAF | N | βinv | seinv | Pinv | fclog | Plog | Praw |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ASAHL | cis | Discovery | rs4859571 | 4:76,857,309 | C/T | 0.24 | 997 | -0.705 | 0.047 | 1.1×10-46 | -1.360 | 3.3×10-44 | 7×10-25 |
ASAHL | cis | Replication | rs2242470 | 4:76,878,688 | G/A | 0.17 | 337 | -0.523 | 0.088 | 6.9×10-9 | -1.280 | 2.6×10-8 | 9.1×10-6 |
Target (abbrv.) | ASAHL |
Target (full name) | N-acylethanolamine-hydrolyzing acid amidase |
Somalogic ID (Sequence ID) | SL008611 (3173-49_2) |
Entrez Gene Symbol | NAAA |
UniProt ID | Q02083 |
UniProt Comment |
|
All locus annotations are based on the sentinel SNP (rs4859571) and 61 proxy variant(s) that is/are in linkage disequilibrium r2 ≥ 0.8. Linkage disequilibrium is based on data from the 1000 Genomes Project, phase 3 version 5, European population and was retrieved using SNiPA's Block Annotation feature.
Download the detailed results of SNiPA's block annotation (PDF)
Genes hit or close-by |
|
Potentially regulated genes | |
eQTL genes |
Trait | P | Study | Source |
---|---|---|---|
Gene expression of ASAHL in peripheral blood monocytes | 9.7×10-31 | 20502693 (PMID) | GRASP2 eQTL |
Gene expression of NAAA in blood | 8.1×10-29 | 21829388 (PMID) | GRASP2 eQTL |
Gene expression of NAAA [probe 214765_s_at] in lymphoblastoid cell lines | 2.1×10-22 | 17873877 (PMID) | GRASP2 eQTL |
Gene expression of NAAA [probe 227135_at] in lymphoblastoid cell lines | 2.5×10-21 | 17873877 (PMID) | GRASP2 eQTL |
Gene expression of ASAHL in lymphoblastoid cell lines | 2×10-20 | 17873877 (PMID) | GRASP2 eQTL |
Gene expression of CXCL10 [probe 204533_at] in lymphoblastoid cell lines | 2.4×10-18 | 17873877 (PMID) | GRASP2 eQTL |
Gene expression of CXCL10 in lymphoblastoid cell lines | 2.7×10-17 | 17873877 (PMID) | GRASP2 eQTL |
Gene expression of NAAA in liver | 2.9×10-15 | 21637794 (PMID) | GRASP2 eQTL |
Gene expression of NAAA (probeID ILMN_2391512) in cerebellum in Alzheimer's disease cases and controls | 2.1×10-12 | 22685416 (PMID) | GRASP2 eQTL |
Gene expression of ASAHL in liver | 2.9×10-11 | 18462017 (PMID) | GRASP2 eQTL |
Gene expression of NAAA (probeID ILMN_2285568) in breast tumors | 3.9×10-11 | 22522925 (PMID) | GRASP2 eQTL |
Gene expression of NAAA (probeID ILMN_1668605) in cerebellum in Alzheimer's disease cases and controls | 3.8×10-10 | 22685416 (PMID) | GRASP2 eQTL |
Gene expression of ASAHL in CEU-CHB-JPT-YRI lymphoblastoid cell lines | 1.3×10-9 | 17873874 (PMID) | GRASP2 eQTL |
Gene expression of NAAA (probeID ILMN_2285568) in temporal cortex in Alzheimer's disease cases and controls | 5.9×10-9 | 22685416 (PMID) | GRASP2 eQTL |
Gene expression of ASAHL in CEU lymphoblastoid cell lines | 3.1×10-8 | 17873874 (PMID) | GRASP2 eQTL |
Gene expression of NAAA in Lymphoblastoid cell lines | 1.6×10-7 | 19644074 (PMID) | GRASP2 eQTL |
Gene expression of NAAA (probeID ILMN_2391512) in temporal cortex in Alzheimer's disease cases and controls | 3.2×10-7 | 22685416 (PMID) | GRASP2 eQTL |
Gene expression of NAAA [probeset 214765_s_at] in sputum | 5.9×10-7 | 21949713 (PMID) | GRASP2 eQTL |
Gene expression of NAAA (probeID ILMN_1668605) in temporal cortex in Alzheimer's disease cases and controls | 1.1×10-6 | 22685416 (PMID) | GRASP2 eQTL |
Gene expression of CXCL11 [probe ILMN_17824] in osteoblasts with treatment interaction | 1.3×10-6 | 21283786 (PMID) | GRASP2 eQTL |
Aging | 5.1×10-6 | 22445811 (PMID) | GRASP2 nonQTL |
Differential exon level expression of ASAHL [probe 2773895] in peripheral blood mononuclear cells | 5.7×10-6 | 19222302 (PMID) | GRASP2 eQTL |
Gene expression of SDAD1 in blood | 6.3×10-6 | 21829388 (PMID) | GRASP2 eQTL |
Gene expression of SLC6A20 in peripheral blood monocytes | 9.2×10-6 | 20502693 (PMID) | GRASP2 eQTL |
Gene expression of CXCL10 in Lymphoblastoid cell lines | 1.4×10-5 | 19644074 (PMID) | GRASP2 eQTL |
Heart rate variability - TP - total power | 1.5×10-5 | 17903306 (PMID) | GRASP2 nonQTL |
Heart rate | 1.5×10-5 | pha001394 (dbGaP) | dbGaP via SNiPA |
Inflammatory bowel disease | 3.7×10-5 | Supplemental file | |
Gene expression of NAAA (probeID ILMN_2285568) in cerebellum in Alzheimer's disease cases and controls | 4.6×10-5 | 22685416 (PMID) | GRASP2 eQTL |
Autism | 1.1×10-4 | 20663923 (PMID) | GRASP2 nonQTL |
Serum ratio of (1-eicosadienoylglycerophosphocholine*)/(1-myristoylglycerophosphocholine) | 1.1×10-4 | 21886157 (PMID) | GRASP2 metabQTL |
Serum concentration of guanosine | 1.3×10-4 | 21886157 (PMID) | GRASP2 metabQTL |
Gene expression of ASAHL [probe 2773872] in peripheral blood mononuclear cells | 1.6×10-4 | 19222302 (PMID) | GRASP2 eQTL |
Gene expression of NAAA (ENSG00000138744) in dendritic cells | 1.7×10-4 | 22233810 (PMID) | GRASP2 eQTL |
Gene expression of NAAA in normal prepouch ileum | 1.9×10-4 | 23474282 (PMID) | GRASP2 eQTL |
Gene expression of NAAA [probeset 227135_at] in sputum | 2.5×10-4 | 21949713 (PMID) | GRASP2 eQTL |
Crohn's disease | 3×10-4 | Supplemental file | |
Autism with verbal ability | 3.3×10-4 | 20663923 (PMID) | GRASP2 nonQTL |