HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Target annotations

Target: Tax1-binding protein 3 (TX1B3)

Target (abbrv.) TX1B3
Target (full name) Tax1-binding protein 3
Somalogic ID (Sequence ID) N/A (12498-12_3)
Entrez Gene Symbol TAX1BP3
UniProt ID O14907
UniProt Comment
  • May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.
pGWAS Locus -