HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Target annotations

Target: Regulator of G-protein signaling 19 (RGS19)

Target (abbrv.) RGS19
Target (full name) Regulator of G-protein signaling 19
Somalogic ID (Sequence ID) N/A (12713-365_3)
Entrez Gene Symbol RGS19
UniProt ID P49795
UniProt Comment
  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
pGWAS Locus -