HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Target annotations

Target: Immunoglobulin M (IgM)

Target (abbrv.) IgM
Target (full name) Immunoglobulin M
Somalogic ID (Sequence ID) SL000468 (3069-52_3)
Entrez Gene Symbol IGHMIGJIGK@IGL@
UniProt ID P01871
UniProt Comment
  • IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts.
Reactome
  • Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
pGWAS Locus -
pGWAS NetworkGo to network view