HelmholtzZentrum munich
WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Target annotations

Target: Platelet glycoprotein VI (GPVI)

Target (abbrv.) GPVI
Target (full name) Platelet glycoprotein VI
Somalogic ID (Sequence ID) SL008759 (3194-36_2)
Entrez Gene Symbol GP6
UniProt ID Q9HCN6
UniProt Comment
  • Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.
Reactome
  • Cell surface interactions at the vascular wall
  • GPVI-mediated activation cascade
  • Platelet Adhesion to exposed collagen
pGWAS Locus 126, 355
pGWAS NetworkGo to network view