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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Target annotations

Target: Stromal cell-derived factor 1 (SDF-1)

Target (abbrv.) SDF-1
Target (full name) Stromal cell-derived factor 1
Somalogic ID (Sequence ID) SL004712 (3516-60_2)
Entrez Gene Symbol CXCL12
UniProt ID P48061
UniProt Comment
  • Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
Biomarker applications (based on IPA annotation)
  • diagnosis
  • efficacy
  • prognosis
  • unspecified application
Wiki Pathways
  • Lymphocyte TarBase
  • Muscle cell TarBase
Pathway Interaction Database
  • CXCR4-mediated signaling events
  • HIF-1-alpha transcription factor network
  • Syndecan-4-mediated signaling events
Reactome
  • Chemokine receptors bind chemokines
  • G alpha (i) signalling events
  • Nuclear signaling by ERBB4
Pathway Studio
  • CXCR4 → STAT signaling
pGWAS Locus -
pGWAS NetworkGo to network view