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WCMC

Connecting genetic risk to disease endpoints through the human blood plasma proteome

ONLINE SUPPLEMENTARY INFORMATION

Ideogram
Proteome annotation
Target annotations

Target: Adenylosuccinate lyase (PUR8)

Target (abbrv.) PUR8
Target (full name) Adenylosuccinate lyase
Somalogic ID (Sequence ID) SL009792 (5023-23_1)
Entrez Gene Symbol ADSL
UniProt ID P30566
UniProt Comment
  • Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
Wiki Pathways
  • Nucleotide Metabolism
UniPathway
  • AMP biosynthesis via de novo pathway
  • IMP biosynthesis via de novo pathway
Reactome
  • Purine ribonucleoside monophosphate biosynthesis
pGWAS Locus -
pGWAS NetworkGo to network view